Linalool 2017-05-18T19:33:22+00:00


Terpene Profile: Linalool, Source: C10H18 O

Molecular Mass: 154.24932 g/mol

Boiling Point: 198 °C (388.4°F)

LD50 (Lethal Dose): Currently Unknown for humans, LD50 = 3g/kg for mice  (Compare to Nicotine: for rats – 50 mg/kg,  for humans – 0.5-1 mg/kg)

Up until now of these profiles have focused specifically on cannabinoids; this post will be the first that shifts the focus to the larger discussion of terpenoids and terpenes. Cannabinoids are a class of terpenophenolic compounds, part terpenoid and part phenol. While terpenes are hydrocarbon groups created by various combinations of the isoprene units that make them up, and may be aromatic, all phenols are aromatic hydrocarbons, which means they have a very pronounced scent. Terpenoids are compounds related to terpenes but may also include oxygen or have molecules rearranged; the terms are often used interchangeably. Cannabinoids, being half terpene and half phenol, have very pronounced scents and flavors. The different combinations of terpenes and cannabinoids found in cannabis are what give strains their distinct flavors and scents, as well as their medicinal properties.
In this first terpene profile we’ll discuss linalool, a common terpene in cannabis although best known for giving lavender its distinct scent and flavor. Linalool is also often used in aromatherapy as a sleep aid, a relaxant and as a treatment for anxiety for thousands of years. Linalool is crucial in the production of Vitamin E in the body, which makes it a very important terpene for healthy functioning.

Connection to GDP?

As stated, linalool is a common terpene found in cannabis. Some laboratory tests show elevated levels of linalool in Grand Daddy Purple, Ken’s GDP, and other purple strains. Laboratory testing shows that not all samples test high in linalool. The Medical Marijuana Handbook co-authored by cannabis guru Ed Rosenthal relates that sampled GDP contained significant amounts of pinene, limonene, borneol, and moderate levels of myrcene and terpenol.” Perhaps the production of linalool is dependent on the phenotype of the strain or some other factor; until more research is done this will remain unknown.

Therapeutic Uses

Analgesic: Relieves pain.

Antidepressant: Relieves symptoms of depression.

Anti-Epileptic: Reduces seizures and convulsions.

Anti-Inflammatory: Reduces inflammation.

Antipsychotic: Tranquilizing effects relieve symptoms of psychosis.

Anxiolytic: Relieves anxiety[? – More research is needed; see below – Ed.]

Sedative: Promotes sleep.

Currently Being Studied For

Cytotoxicity: In a 2004 study, Lavender oil, which is a mix of linalool and other natural compounds, was shown to be toxic to human skin cells. But don’t fear it required a very high concentration of lavender oil to have a negative effect, and for methodological reasons the study did not implicate linalool so much as the overall mix of compounds in lavender oil. Pure linalool has not been similarly studied.
Anti-Inflammatory: Linalool has been shown to be a major anti-inflammatory agent in the essential oils that contain it, according to this study from the Journal of Phytomedicine (2002). This seems to indicate that any toxicity would not be coming from the linalool, as it would be acting to abate the inflammation.
Analgesic: Peana et al built off their 2002 study which showed linalool to be an anti-inflammatory and went on in 2003 to show that is was an analgesic as well. The analgesic and anti-inflammatory effects appeared to be the result of antinociception, which means linalool blocks the feelings of pain rather than using another mechanism to reduce painful feelings. This 2006 study, also by Peana, further examined the mechanisms linalool uses to prevent pain and inflammation, and provided more evidence that it is a powerful anti-inflammatory.
Anticonvulsant: In this study on mice, three sub-types of linalool were examined to see their anticonvulsant properties. While all were shown to help prevent convulsions, they were effective at different doses and R-linalool seemed to be more effective in some cases. This means linalool could be a potential treatment for seizures.
Sedative: While this 2008 study unsuccessfully tried to prove the anxiolytic effects of linalool it provided strong support for evidence of its sedative qualities. Now there is solid evidence to support thousands of years of traditional medicine that relied on using linalool to promote relaxation and sleep.

You can read the original reference here: The Leaf Online